“Every year you learn new things. This is not the end goal for us,” said Wyatt Johnston, who at 22 has already been to three West finals. “You need to go through the conference final. ... Our goal is to win the Stanley Cup. I think you always want to learn, and I think that’s good that you can learn from it, but we want to win.”
While Montgomery is thrilled with Looney’s progress, he’s done most work using Revivicor pigs with just, in a xenotransplant last April and in research with the deceased.
“Our feeling is, you know, less is more,” said Montgomery, noting it’s easier to mass produce pigs with fewer gene alterations. Looney’s transplant offers a chance to compare “really how much difference those additional gene edits are making.”In Boston, eGenesis has still another approach – a whopping 69 gene edits. In addition to 10 genetic alterations to improve human compatibility, genes linked to certain pig viruses also are inactivated.Researchers feel pressure to show if pig organs can keep people alive much longer than a few months, said eGenesis’ Curtis. If not, the question will be “do we have the right gene edits?”
The balance is choosing participants sick enough to qualify but not so sick they have no chance.“There’s a tremendous number of patients who would be very willing, very willing to do this,” said Dr. Silke Niederhaus of the University of Maryland, who isn’t involved in xenotransplant research but watches it closely.
Niederhaus became a kidney transplant surgeon because around her 12th birthday, one saved her life. That kidney lasted three decades. When it failed, it took five years to find another. So she understands the draw of pig research, and urges people to learn their odds of getting a human kidney before volunteering.
If they’re younger, healthier or have a living donor, “I would probably say go with what’s known and what’s proven,” Niederhaus said. But if they’re older and dialysis is starting to fail, “maybe it’s worth taking the risk.”Mexico’s government has been working furiously to talk U.S. President Donald Trump down from tariff threats and meet demands by his administration to crack down on organized crime. At the same time, Trump has been
with courts trying to block various actions.The turmoil could hurt international investment in Mexico if investors believe their money is less secure, Zissis said.
“It feels like Mexico is opening a Pandora’s box,” she said.Associated Press journalists María Verza and Christian Chávez contributed to this report from Mexico City and Ciudad Juarez, Mexico.